Transport of HIV-Protease Inhibitors Across 1α,25di-Hydroxy Vitamin D3-Treated Calu-3 Cell Monolayers: Modulation of P-Glycoprotein Activity

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

Medicine, Biochemistry, Pharmacology +15

A Controlled Trial of Two Nucleoside Analogues plus Indinavir in Persons with Human Immunodeficiency Virus Infection and CD4 Cell Counts of 200 per Cubic Millimeter or Less

Scott M. Hammer, Kathleen Squires, Michael D. Hughes et al. · New England Journal of Medicine · 1997 · 2.7K citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +17

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

Richard B. Kim, Martin F. Fromm, Christoph Wandel et al. · Journal of Clinical Investigation · 1998 · 1.1K citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

Rational Use of in Vitro P-glycoprotein Assays in Drug Discovery

Joseph W. Polli, Stephen A. Wring, Joan E. Humphreys et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 662 citations

Pharmacy, Pharmacokinetics, Pharmacology +14

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.

Joseph C. Kolars, Phyllissa Schmiedlin‐Ren, John D. Schuetz et al. · Journal of Clinical Investigation · 1992 · 533 citations · Full text

Medicine, Molecular Biology, Pharmacology +14