The Design and Evaluation of Heparin‐Binding Foldamers

Abstract

Controlling blood loss: The synthesis of a series of arylamide oligomers 1, which interact with heparin is described. The heparin–small molecule interaction inhibits the heparin's ability to activate antithrombin. These arylamide oligomers are the first example of low-molecular-weight antagonists that inhibit the anticoagulant function of heparin.