Association of <i>HTR2C</i> , But Not <i>LEP</i> or <i>INSIG2</i> , Genes with Antipsychotic-Induced Weight Gain in a German Sample

Abstract

The results contribute to the accumulating evidence for an association of the X-chromosomal HTR2C gene with antipsychotic-induced BWG. The proposed underlying mechanisms include decreased HTR2C gene expression with reduced 5-HT-modulated activation of hypothalamic proopiomelanocortin-neurons, and inverse 5-HT(2C) agonism in the presence of D(2) receptor antagonism.