Antimicrobial Agents and Chemotherapy · 1986 · 93 citations · 17 references
Life SciencesBiotechnologyMicrobiologyMicrobial BiotechnologyMicrobial MetabolismNatural Product BiosynthesisAntibiotic FermentationAntibiotic ProductionMicrobial Metabolic EngineeringMicrobial Metabolite ProductionMicrobial Natural Product BiosynthesisMicrobial Synthetic BiologyAntibiotic DiscoveryBacteriocin ProductionComparative BiosynthesisConserved Gene ClustersMicrobial Genome-encoded BiosynthesisMicrobial Synthesis PathwaysProduction Of Antimicrobial CompoundsResistance Gene Clusters
Hybrid antibiotics mederrhodins A and B were produced by a recombinant strain consisting of the medermycin-producing Streptomyces sp. strain AM7161 containing part of the gene clusters for actinorhodin biosynthesis of Streptomyces coelicolor A3(2). Mederrhodin A has a hydroxyl group at the C-6 position of the medermycin molecule, and mederrhodin B is dihydromederrhodin A. The antimicrobial activity of mederrhodin A resembled that of medermycin. Mederrhodin B was almost devoid of antimicrobial activity.
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Production of ‘hybrid’ antibiotics by genetic engineering
David A. Hopwood, Francisco Malpartida, Helen M. Kieser et al. · Nature · 1985 · 367 citations