The Journal of Immunology · 1999 · 179 citations · 16 references
Life SciencesInfectious DiseasesMolecular BiologyImmunology Of Infectious DiseasesMolecular VirologyVirologyAntiviral ImmunityViral EntryViral Immune EvasionViral InfectionsViral PathogenesisViral PathologyAntiviral Innate SignalingAntiviral RecognitionAntiviral Signaling PathwaysCytomegalovirus DiseaseViral Evasion MechanismsViral GlycoproteinsViral Immune Evasion MechanismsViral Immune Evasion Signaling
The UL144 open reading frame found in clinical isolates of human CMV (HCMV) encodes a structural homologue of the herpesvirus entry mediator, a member of the TNFR superfamily. UL144 is a type I transmembrane glycoprotein that is expressed early after infection of fibroblasts; however, it is retained intracellularly. A YXXZ motif in the highly conserved cytoplasmic tail contributes to UL144 subcellular distribution. The finding that no known ligand of the TNF family binds UL144 suggests that its mechanism of action is distinct from other known viral immune evasion genes. Specific Abs to UL144 can be detected in the serum of a subset of HCMV seropositive individuals infected with HIV. This work establishes a novel molecular link between the TNF superfamily and herpesvirus that may contribute to the ability of HCMV to escape immune clearance.
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Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
Margot Thome, Pascal Schneider, Kay Hofmann et al. · Nature · 1997 · 1.3K citations · Full text