Cathepsin L Inactivates Human Trypsinogen, Whereas Cathepsin L-Deletion Reduces the Severity of Pancreatitis in Mice

Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene

David C. Whitcomb, Michael C. Gorry, Robert A. Preston et al. · Nature Genetics · 1996 · 1.6K citations

Medicine, Genetics, Molecular Genetics +12

Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus

T Nakagawa, Wera Roth, Phillip Wong et al. · Science · 1998 · 662 citations

Life Sciences, Cell Biology, Immunology +17

Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study

EA Kemppainen, JM Mayer, J. Michael Fitzpatrick et al. · The Lancet · 2000 · 622 citations

Medicine, Pathobiology, Early Detection +6

Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis

Walter Halangk, Markus M. Lerch, Barbara Brandt-Nedelev et al. · Journal of Clinical Investigation · 2000 · 566 citations · Full text

Medicine, Pathobiology, Pathology +14

Selective Disruption of Lysosomes in HeLa Cells Triggers Apoptosis Mediated by Cleavage of Bid by Multiple Papain-like Lysosomal Cathepsins

Tina Cirman, Kristina Orešić, Gabriela Droga Mazovec et al. · Journal of Biological Chemistry · 2004 · 470 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17