Cancer Research · 2004 · 215 citations · 14 references
MedicineGeneticsRadiation OncologyGene ExpressionRadiation DosimetryRadiobiologyBiological Effects Of RadiationCellular Radiation ResponseRadiation BiologyRadiation HealthRadiation TherapyTissue Responses To RadiationBiological DosimetryBiomarkersMicroarray AnalysisRadiation BiomarkersRadiation Response BiomarkersRadiation Response Gene ExpressionRadiation Stress ResponsesRadiation-induced Gene Expression
After initially identifying potential biomarkers of radiation exposure through microarray studies of ex vivo irradiated human peripheral white blood cells, we have now measured the in vivo responses of several of these biomarker genes in patients undergoing total body irradiation. Microarray analysis has identified additional in vivo radiation-responsive genes, although the general in vivo patterns of stress-gene induction appear similar to those obtained from ex vivo white blood cell experiments. Additional studies may reveal correlations between responses and either diagnosis or prognosis, and such in vivo validation marks an important step in the development of potentially informative radiation exposure biomarkers.
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Identifying biological themes within lists of genes with EASE
Douglas A Hosack, Glynn Dennis, Brad T. Sherman et al. · Genome biology · 2003 · 2K citations · Full text
p21 is necessary for the p53-mediated G1 arrest in human cancer cells.
Todd Waldman, K. W. Kinzler, Bert Vogelstein · PubMed · 1995 · 1.2K citations