Concepedia

A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant

Scott A. Halperin, Gary Van Nest, Bruce R. Smith, Simin Abtahi, Heather Whiley, Joseph Eiden

Vaccine · 2003 · 260 citations · 35 references

DOI

Concepts

References

35

CpG motifs in bacterial DNA trigger direct B-cell activation

Arthur Μ. Krieg, Ae‐Kyung Yi, Sara Matson et al. · Nature · 1995 · 3.5K citations

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CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

Dennis M. Klinman, Ae‐Kyung Yi, Serge L. Beaucage et al. · Proceedings of the National Academy of Sciences · 1996 · 1.5K citations

, , +17

Hepatitis B Vaccine

W. Szmuness, Cladd E. Stevens, Edward J. Harley et al. · New England Journal of Medicine · 1980 · 1.1K citations

, , +17

Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization

Yukio Sato, Mark Roman, Helen Tighe et al. · Science · 1996 · 1.1K citations

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CpG Oligodeoxynucleotides Act as Adjuvants that Switch on T Helper 1 (Th1) Immunity

Rose S. Chu, Oleg S. Targoni, Arthur Μ. Krieg et al. · The Journal of Experimental Medicine · 1997 · 1K citations · Full text

, , +16