Patient‐derived dendritic cells transduced with an a‐fetoprotein‐encoding adenovirus and co‐cultured with autologous cytokine‐induced lymphocytes induce a specific and strong immune response against hepatocellular carcinoma cells

Abstract

The data demonstrate that patient-derived DCs that were transduced with an AFP-expressing adenovirus and co-cultured with autologous CIK cells induce an AFP-specific, strong immune response against HCC cells. Therefore, this approach may have a potential for an adoptive and/or DC-based immunotherapy for HCC patients.