Concepedia

Expression of B-cell activating factor of the tumour necrosis factor family (BAFF) in T cells in active systemic lupus erythematosus: the role of BAFF in T cell-dependent B cell pathogenic autoantibody production

Shinji Morimoto, Souichiro Nakano, Takashi Watanabe, Y. Tamayama, Akiko Mitsuo, Yutaka Nakiri, Jun Suzuki, Kazuki Nozawa, Hirofumi Amano, Yoshiaki Tokano,

Lara D. Veeken · 2007 · 75 citations · 27 references

DOI

Abstract

BAFF may play a pathogenic role in SLE by stimulating T cell-dependent B cell autoantibodies production. Blockade of BAFF is a promising therapeutic approach for SLE especially in patients with kidney involvement.

References

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Pascal Schneider, Fabienne Mackay, Véronique Steiner et al. · The Journal of Experimental Medicine · 1999 · 1.3K citations · Full text

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Paul A. Moore, Ornella Belvedere, A. S. ORR et al. · Science · 1999 · 1.1K citations

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