Concepedia

Utilization of in vitro Caco‐2 permeability and liver microsomal half‐life screens in discovering BMS‐488043, a novel HIV‐1 attachment inhibitor with improved pharmacokinetic properties

Zheng Yang, Lisa Zadjura, Anthony M. Marino, Celia D’Arienzo, Jacek Malinowski, Christoph Gesenberg, Pin‐Fang Lin, Richard J. Colonno, Tao Wang, John F. Kadow,

Journal of Pharmaceutical Sciences · 2009 · 22 citations · 19 references

DOI

Concepts

References

19

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data

Kaoxiang Sun · Chinese New Drugs Journal · 2005 · 764 citations

, , +16

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

R. Scott Obach, James G. Baxter, Theodore E. Liston et al. · PubMed · 1997 · 638 citations

The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data

R. Scott Obach, James G. Baxter, Theodore E. Liston et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 574 citations

, , +11

A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding

Pin‐Fang Lin, Wade Blair, Tao Wang et al. · Proceedings of the National Academy of Sciences · 2003 · 360 citations · Full text

, , +19

Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol.

R S Obach · PubMed · 1997 · 281 citations

, , +21