Continuous Enzymatic Synthesis of 2′‐Deoxythymidine‐5′‐(α‐<scp>D</scp>‐glucopyranosyl)diphosphate

Abstract

The preparation of primary nucleotide sugars like 1 with sucrose synthase, a glycosyl transferase in plants, provides an alternative in enzymatic synthesis to the use of highly specific pyrophosphorylases. In an enzyme membrane reactor a continuous synthesis can be performed on preparative scale.