Exendin-4 regulates lipid metabolism and fibroblast growth factor 21 in hepatic steatosis

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Joseph T. Rodgers, Carles Lerín, Wilhelm Haas et al. · Nature · 2005 · 3.1K citations

Life Sciences, Molecular Biology, Physiology +14

FGF-21 as a novel metabolic regulator

Alexei Kharitonenkov, Tatiyana L. Shiyanova, Anja Köester et al. · Journal of Clinical Investigation · 2005 · 2.1K citations · Full text

Life Sciences, Biochemistry, Endocrinology +17

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

Jing Xu, David J. Lloyd, Clarence Hale et al. · Diabetes · 2008 · 1.1K citations · Full text

Life Sciences, Biochemistry, Endocrinology +17

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

Aparna Purushotham, Thaddeus T. Schug, Qing Xu et al. · Cell Metabolism · 2009 · 1.1K citations · Full text

Life Sciences, Biochemistry, Cell Biology +16

Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans

Xinmei Zhang, Dennis C.Y. Yeung, Michal Karpíšek et al. · Diabetes · 2008 · 895 citations

Medicine, Biochemistry, Endocrinology +16