Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

Jing Xu, David J. Lloyd, Clarence Hale, +13

Diabetes

Sterol Regulatory Element Binding Protein-1 Expression Is Suppressed by Dietary Polyunsaturated Fatty Acids

Jing Xu, Manabu Nakamura, Hyekyung P. Cho, +1

Journal of Biological Chemistry

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects

Jing Xu, Shanaka Stanislaus, Narumol Chinookoswong, +13

American Journal of Physiology-Endocrinology and Metabolism

Insulin-sensitizing ActionGlucose ToleranceFgf21 ActionsInsulin SignalingTypical Fgf Signaling +20

Polyunsaturated Fatty Acids Suppress Hepatic Sterol Regulatory Element-binding Protein-1 Expression by Accelerating Transcript Decay

Jing Xu, Margarita Terán‐García, Jung H.Y. Park, +2

Journal of Biological Chemistry

Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance

Clarence Hale, Michelle Chen, Shanaka Stanislaus, +5

Endocrinology

Metabolic DisorderCaloric RestrictionPotential Fgf21 ResistanceInsulin SignalingObesity +23

Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes

Randy Hecht, Yuesheng Li, Jeonghoon Sun, +18

PLoS ONE

Human GrowthPeptide ScienceBiomedical EngineeringNative Fgf21Rationale-based Engineering +22

Secondary follicle growth and oocyte maturation during encapsulated three-dimensional culture in rhesus monkeys: effects of gonadotrophins, oxygen and fetuin

Jing Xu, Maralee S. Lawson, Richard R. Yeoman, +4

Human Reproduction

Rapid Mitochondrial DNA Segregation in Primate Preimplantation Embryos Precedes Somatic and Germline Bottleneck

Hyo-Sang Lee, Hong Ma, Rita Cervera Juanes, +9

Cell Reports

FGF21 N‐ and C‐termini play different roles in receptor interaction and activation

Junming Yie, Randy Hecht, Jennifer Patel, +16

FEBS Letters

Cellular PhysiologyMolecular PharmacologySignaling PathwayCell RegulationReceptor Tyrosine Kinase +16

Long-Acting FGF21 Has Enhanced Efficacy in Diet-Induced Obese Mice and in Obese Rhesus Monkeys

Murielle M. Véniant, Renée Komorowski, Ping Chen, +7

Endocrinology

NutritionMetabolic DisorderMurine Recombinant Fgf21ObesityMetabolic Syndrome +15