Concepedia

Mechanical Ventilation–induced Diaphragm Disuse in Humans Triggers Autophagy

Sabah N. A. Hussain, Mahroo Mofarrahi, Ioanna Sigala, Ho Cheol Kim, Theodoros Vassilakopoulos, François Maltais, Ion Bellenis, Rakesh Chaturvedi, Stewart B. Gottfried, Peter Metrakos,

American Journal of Respiratory and Critical Care Medicine · 2010 · 263 citations · 52 references

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Open access

Abstract

We propose that prolonged CMV causes diaphragm disuse, which, in turn, leads to activation of the ALP through oxidative stress and the induction of the FOXO1 transcription factor.

References

52

Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy

Marco Sandri, Claudia Sandri, Alex Gilbert et al. · Cell · 2004 · 2.9K citations · Full text

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Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

Sue C. Bodine, Trevor N. Stitt, Michael Gonzalez et al. · Nature Cell Biology · 2001 · 2.7K citations

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FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

Cristina Mammucari, Giulia Milan, Vanina Romanello et al. · Cell Metabolism · 2007 · 1.9K citations · Full text

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Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

Stewart H. Lecker, R. Thomas Jagoe, Alexander D. Gilbert et al. · The FASEB Journal · 2004 · 1.5K citations

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Rapid Disuse Atrophy of Diaphragm Fibers in Mechanically Ventilated Humans

Sanford Levine, Taitan Nguyen, Nyali Taylor et al. · New England Journal of Medicine · 2008 · 1.5K citations · Full text