Mechanical Ventilation–induced Diaphragm Disuse in Humans Triggers Autophagy - Concepedia

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Publication | Open Access

Mechanical Ventilation–induced Diaphragm Disuse in Humans Triggers Autophagy

DOI Full Paper Access

263

Citations

52

References

2010

Year

Sabah N. A. Hussain, Mahroo Mofarrahi, Ioanna Sigala, Ho Cheol Kim, Theodoros Vassilakopoulos, François Maltais, Ion Bellenis, Rakesh Chaturvedi, Stewart B. Gottfried, Peter Metrakos,

American Journal of Respiratory and Critical Care Medicine

Abstract

We propose that prolonged CMV causes diaphragm disuse, which, in turn, leads to activation of the ALP through oxidative stress and the induction of the FOXO1 transcription factor.

References

	Year	Citations
Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy Marco Sandri, Claudia Sandri, Alex Gilbert, Cell Transcriptional RegulationSkeletal MuscleGeneticsMolecular GeneticsGene Expression	2004	2.9K
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo Sue C. Bodine, Trevor N. Stitt, Michael Gonzalez, Nature Cell Biology Skeletal Muscle HypertrophyMolecular PhysiologyMuscle InjuryMuscle FunctionSkeletal Muscle	2001	2.7K
FoxO3 Controls Autophagy in Skeletal Muscle In Vivo Cristina Mammucari, Giulia Milan, Vanina Romanello, Cell Metabolism Cell AutophagyMitophagySkeletal MusclePhysiologyAutophagy	2007	1.9K
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression Stewart H. Lecker, R. Thomas Jagoe, Alexander D. Gilbert, The FASEB Journal Muscle FunctionGeneticsMuscle Atrophy ShareGene CharacterizationMolecular Genetics	2004	1.5K
Rapid Disuse Atrophy of Diaphragm Fibers in Mechanically Ventilated Humans Sanford Levine, Taitan Nguyen, Nyali Taylor, New England Journal of Medicine	2008	1.5K
FoxO3 Coordinately Activates Protein Degradation by the Autophagic/Lysosomal and Proteasomal Pathways in Atrophying Muscle Cells Jinghui Zhao, Jeffrey J. Brault, Andreas Schild, Cell Metabolism Cell AutophagyMitophagyProtein FunctionAtrophying Muscle CellsSkeletal Muscle	2007	1.4K
Percutaneous Needle Biopsy of Skeletal Muscle in Physiological and Clinical Research Jonas Bergström Scandinavian Journal of Clinical and Laboratory Investigation Gross AnatomyMuscle PathologySkeletal MuscleHistopathologySurgery	1975	973
Percutaneous Needle Biopsy of Skeletal Muscle in Physiological and Clinical Research Jonas Bergström Scandinavian Journal of Clinical and Laboratory Investigation Muscle PathologyGross AnatomyKinesiologyMuscle InjuryMuscle Function	1975	971
PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription Marco Sandri, Jiandie D. Lin, Christoph Handschin, Proceedings of the National Academy of Sciences	2006	953
Skeletal Muscle FOXO1 (FKHR) Transgenic Mice Have Less Skeletal Muscle Mass, Down-regulated Type I (Slow Twitch/Red Muscle) Fiber Genes, and Impaired Glycemic Control Yasutomi Kamei, Shinji Miura, Miki Suzuki, Journal of Biological Chemistry	2004	561

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