Mammalian microRNAs predominantly act to decrease target mRNA levels

Huili Guo, Nicholas T. Ingolia, Jonathan S. Weissman, +1

Nature

Mammalian MicrornasMicrorna DetectionSmall RnaGene ExpressionMedicine +3

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Randy Strong, Z. Dave Sharp, James F. Nelson, +10

Nature

Lifespan ExtensionAgingRapamycin FedHeterogeneous MiceLongevity +9

A C. elegans mutant that lives twice as long as wild type

Cynthia Kenyon, Jean Chang, Erin Gensch, +2

Nature

BiologyWild TypeLongevityGeneticsMolecular Genetics +1

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

C C Mello, James M. Kramer, Dan T. Stinchcomb, +1

The EMBO Journal

Efficient Gene TransferDevelopmental BiologyGeneticsGenetic EngineeringGenetic Mechanism +6

Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase

Haim Cohen, Christine Miller, Kevin J. Bitterman, +7

Science

Anti-agingCell DeathCell LossBiogerontologyCaloric Restriction +18

Dicer is essential for mouse development

Emily Bernstein, Sang Yong Kim, Michelle A. Carmell, +7

Nature Genetics

Knockout MouseDevelopmental BiologyCell Fate DeterminationMedicineCell Biology +1

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

Matthias Blüher, Barbara B. Kahn, C. Ronald Kahn

Science

AgingInsulin ReceptorCaloric RestrictionInsulin SignalingObesity +14

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

Chryssa Kanellopoulou, Stefan A. Muljo, Andrew L. Kung, +5

Genes & Development

Adipose Tissue Selective Insulin Receptor Knockout Protects against Obesity and Obesity-Related Glucose Intolerance

Matthias Blüher, M.Dodson Michael, Odile D. Peroni, +4

Developmental Cell

ObesityMetabolic SyndromeInsulin SignalingMedicineInsulin Management +10

An AMPK-FOXO Pathway Mediates Longevity Induced by a Novel Method of Dietary Restriction in C. elegans

Eric Lieberman Greer, Dara P. Dowlatshahi, Max R. Banko, +5

Current Biology

BiologyCaloric RestrictionLifespan ExtensionNovel MethodLongevity +8