Concepedia

Prion‐removal capacity of chromatographic and ethanol precipitation steps used in the production of albumin and immunoglobulins

James M. Thyer, Arzu Ünal, P. P. Thomas, B.M. Eaton, R. Bhashyam, J. Ortenburg, Eric Uren, DJ Middleton, P. W. Selleck, D. Maher

Vox Sanguinis · 2006 · 28 citations · 26 references

DOI

Abstract

Using rodent-adapted scrapie as a model, the studies indicated that ion exchange chromatography, as well as Cohn immunoglobulin fractionation have the potential to effectively reduce the load of TSE agents should they be present in plasma pools.

References

26

Preparation and Properties of Serum and Plasma Proteins. IV. A System for the Separation into Fractions of the Protein and Lipoprotein Components of Biological Tissues and Fluids<sup>1a,b,c,d</sup>

E. J. Cohn, L. E. Strong, William L. Hughes et al. · Journal of the American Chemical Society · 1946 · 1.8K citations

, , +21

Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion

C. A. Llewelyn, P. B Hewitt, RSG Knight et al. · The Lancet · 2004 · 1.1K citations

, , +6

Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient

Alexander Peden, Mark Head, L Ritchie Diane et al. · The Lancet · 2004 · 854 citations

, , +6

Separation and properties of cellular and scrapie prion proteins.

R. Meyer, Michael P. McKinley, K A Bowman et al. · Proceedings of the National Academy of Sciences · 1986 · 620 citations · Full text

, , +13

Identification of a gene which controls the incubation period of some strains of scrapie agent in mice

A.G. Dickinson, Veronica M. H. Meikle, H. Fraser · Journal of Comparative Pathology · 1968 · 428 citations

, , +9