Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

Scott A. Armstrong, Jane Staunton, Lewis B. Silverman et al. · Nature Genetics · 2001 · 1.7K citations

Hematological Malignancy, Chromatin, Distinct Gene Expression +12

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H ⁺ -ATPase

Roberto Zoncu, Liron Bar‐Peled, Alejo Efeyan et al. · Science · 2011 · 1.6K citations · Full text

Lysosomal Amino Acids, Molecular Biology, Mtor Pathway +20

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

Matt Kaeberlein, Ryan Powers, Kristan K. Steffen et al. · Science · 2005 · 1.3K citations

Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway

Pankaj Kapahi, Brian M. Zid, Tony Harper et al. · Current Biology · 2004 · 1.3K citations · Full text

Biology, Lifespan Extension, Longevity +6

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

Su-Ju Lin, Matt Kaeberlein, Alex A. Andalis et al. · Nature · 2002 · 1.1K citations

Biology, Caloric Restriction, Lifespan Extension +10