Catalytic Asymmetric Synthesis of Substituted Morpholines and Piperazines

Huimin Zhai, Andrey Borzenko, Ying Yin Lau, Shin Hye Ahn, Laurel L. Schafer

Angewandte Chemie International Edition · 2012 · 86 citations · 67 references

Abstract

Under two conditions: Hydroamination catalyzed by group 4 metals is featured in the modular and enantioselective synthesis of 3-substituted morpholines and the diastereoselective synthesis of 2,5-substituted piperazines. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

References

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