Concepedia

Cyclin D1 Overexpression and Response to Bortezomib Treatment in a Breast Cancer Model

Yuki Ishii, Andreja Pirkmaier, James V. Alvarez, David A. Frank, Inna Keselman, Diomedes E. Logothetis, John Mandeli, Matthew J. O’Connell, Samuel Waxman, Doris Germain

JNCI Journal of the National Cancer Institute · 2006 · 65 citations · 34 references

DOIFull text

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Abstract

Cyclin D1 repression of STAT3 expression may explain the association between cyclin D1 overexpression and improved outcome in breast cancer. In addition, bortezomib can amplify the proapoptotic function of cyclin D1, raising the possibility that cyclin D1 levels may be a marker for predicting the response to this novel drug.

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