Statistical significance for genomewide studies

John D. Storey, Robert Tibshirani

Proceedings of the National Academy of Sciences

GeneticsGenomicsHigh Throughput SequencingFalse Positive RateGenome-wide Association Studies +19

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Mihael H. Polymeropoulos, Christian Lavedan, Elisabeth Leroy, +17

Science

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Tohru Kitada, Shuichi Asakawa, Nobutaka Hattori, +5

Nature

Molecular NeuroscienceMendelian DisorderGenetic DisorderGeneticsParkinson Disease +5

Complement Factor H Polymorphism in Age-Related Macular Degeneration

Robert J. Klein, Caroline J. Zeiss, Emily Y. Chew, +12

Science

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in <i>PINK1</i>

Enza Maria Valente, Patrick M. Abou‐Sleiman, Viviana Caputo, +18

Science

Neurodegenerative DiseasesMitophagyMitochondrial FunctionDegenerative DiseasesDopaminergic Neurons +12

Genomic Control for Association Studies

Bernie Devlin, Kathryn Roeder

Biometrics

Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology

Alexander Zimprich, Saskia Biskup, Petra Leitner, +19

Neuron

Mendelian DisorderGenetic DisorderParkinson DiseaseGeneticsPleomorphic Pathology +3

Mutations in the <i>DJ-1</i> Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

Vincenzo Bonifati, Patrizia Rizzu, Marijke J. van Baren, +15

Science

GeneticsDisease Gene IdentificationSocial SciencesMendelian DisorderDj-1 Protein +14

X-inactivation profile reveals extensive variability in X-linked gene expression in females

Laura Carrel, Huntington F. Willard

Nature

Developmental BiologyGenetic DisorderGeneticsGenomic MechanismGenetic Mechanism +9

Selecting a Maximally Informative Set of Single-Nucleotide Polymorphisms for Association Analyses Using Linkage Disequilibrium

Christopher S. Carlson, Michael A. Eberle, Mark J. Rieder, +3

The American Journal of Human Genetics

Genome-wide Association StudyLinkage DisequilibriumSingle-nucleotide PolymorphismsGenotype-phenotype AssociationMedicine +10