Concepedia

Cadherin-13, a Mediator of Calcium-Dependent Cell-Cell Adhesion, Is Silenced by Methylation in Chronic Myeloid Leukemia and Correlates With Pretreatment Risk Profile and Cytogenetic Response to Interferon Alfa

José Román‐Gómez, Juan A. Castillejo, Antonio Jiménez, Francisco Cervantes, Concepción Boqué, Lourdes Hermosín, Ángel León, A Grañena, Dolors Colomer, Anabel Heiniger,

Journal of Clinical Oncology · 2003 · 96 citations · 38 references

DOI

Abstract

Our data indicate that the silencing of CDH13 expression by aberrant promoter methylation occurs at an early stage in CML pathogenesis and probably influences the clinical behavior of the disease.

References

38

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

James G. Herman, Jeremy R. Graff, Sanna Myöhänen et al. · Proceedings of the National Academy of Sciences · 1996 · 5.6K citations · Full text

, , +21

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

Elizabeth E. Cameron, Kurtis E. Bachman, Sanna Myöhänen et al. · Nature Genetics · 1999 · 1.9K citations

, , +12

The molecular biology of chronic myeloid leukemia

Michael W. Deininger, John M. Goldman, Junia V. Melo · Blood · 2000 · 1.6K citations

Prognostic discrimination in "good-risk" chronic granulocytic leukemia

JE Sokal, Cox Eb, Michele Baccarani et al. · Blood · 1984 · 1K citations · Full text

Prognostic discrimination in "good-risk" chronic granulocytic leukemia

JE Sokal, Cox Eb, Michele Baccarani et al. · Blood · 1984 · 954 citations