Concepedia

Characterization of T cell epitopes in αs1‐casein in cow's milk allergic, atopic and non‐atopic children

Bert Ruiter, Virginie Trégoat, Laura M’Rabet, Johan Garssen, Carla A.F.M. Bruijnzeel-Koomen, Edward F. Knol, Els van Hoffen

Clinical & Experimental Allergy · 2006 · 61 citations · 20 references

DOI

Abstract

The immunodominant sequence in alphas1-casein is spanned by AA residues 133-156. Tolerance towards alphas1-casein in atopic children may be mediated by an overall induction of IL-10 and not by recognition of certain T cell epitopes. The identified T cell epitopes in children with cow's milk allergy may be useful targets in developing peptide immunotherapy.

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