Concepedia

Impaired Mitochondrial Function and Insulin Resistance of Skeletal Muscle in Mitochondrial Diabetes

Julia Szendroedi, A. Schmid, Martin Meyerspeer, Camilla Cervin, Michaela Kacerovsky, Gerhard Smekal, Sabine Gräser-Lang, Leif Groop, Michael Roden

Diabetes Care · 2009 · 79 citations · 8 references

DOIFull text

Open access

Abstract

Impairment of muscle mitochondrial fitness promotes insulin resistance and could thereby contribute to the development of diabetes in some patients with the MELAS syndrome.

References

8

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

Kitt Falk Petersen, Sylvie Dufour, Douglas E. Befroy et al. · New England Journal of Medicine · 2004 · 2.2K citations · Full text

Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance

Kitt Falk Petersen, Douglas E. Befroy, Sylvie Dufour et al. · Science · 2003 · 2.1K citations · Full text

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Mutation in mitochondrial tRNALeu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness

J. M. W. van den Ouweland, H.H.P.J. Lemkes, W. Ruitenbeek et al. · Nature Genetics · 1992 · 1.1K citations

, , +9

Muscle Mitochondrial ATP Synthesis and Glucose Transport/Phosphorylation in Type 2 Diabetes

Julia Szendroedi, A. Schmid, Marek Chmelík et al. · PLoS Medicine · 2007 · 247 citations · Full text

Vascular viewpoint

Fahad Razak, Sonia S. Anand · Vascular Medicine · 2004 · 134 citations

, , +11