Impaired Mitochondrial Function and Insulin Resistance of Skeletal Muscle in Mitochondrial Diabetes - Concepedia

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Publication | Open Access

Impaired Mitochondrial Function and Insulin Resistance of Skeletal Muscle in Mitochondrial Diabetes

DOI Full Paper Access

79

Citations

8

References

2009

Year

Julia Szendroedi, A. Schmid, Martin Meyerspeer, Camilla Cervin, Michaela Kacerovsky, Gerhard Smekal, Sabine Gräser-Lang, Leif Groop, Michael Roden

Abstract

Impairment of muscle mitochondrial fitness promotes insulin resistance and could thereby contribute to the development of diabetes in some patients with the MELAS syndrome.

References

	Year	Citations
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes Kitt Falk Petersen, Sylvie Dufour, Douglas E. Befroy, New England Journal of Medicine	2004	2.2K
Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance Kitt Falk Petersen, Douglas E. Befroy, Sylvie Dufour, Science AgingMetabolic DisorderMitochondrial DysfunctionInsulin SignalingMetabolic Syndrome	2003	2.1K
Mutation in mitochondrial tRNALeu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness J. M. W. van den Ouweland, H.H.P.J. Lemkes, W. Ruitenbeek, Nature Genetics Genetic DeterminantMendelian DisorderGenetic DisorderGeneticsDiabetes	1992	1.1K
Muscle Mitochondrial ATP Synthesis and Glucose Transport/Phosphorylation in Type 2 Diabetes Julia Szendroedi, A. Schmid, Marek Chmelík, PLoS Medicine	2007	247
Vascular viewpoint Fahad Razak, Sonia S. Anand Vascular Medicine Insulin ResistanceMetabolic SyndromeMetabolic DisorderCardiometabolic RiskInsulin Management	2004	134
Clinical Phenotypes, Insulin Secretion, and Insulin Sensitivity in Kindreds With Maternally Inherited Diabetes and Deafness Due to Mitochondrial tRNALeu(UUR) Gene Mutation Gilberto Velho, Maria M. Byrne, Karine Clément, Diabetes Metabolic DisorderGeneticsGenetic EpidemiologyGlucose ToleranceInsulin Signaling	1996	127
Direct noninvasive quantification of lactate and high energy phosphates simultaneously in exercising human skeletal muscle by localized magnetic resonance spectroscopy Martin Meyerspeer, Graham J. Kemp, Vladı́mir Mlynárik, Magnetic Resonance in Medicine	2007	44
Insulin Resistance in Patients with the Mitochondrial tRNA<sup>Leu(UUR)</sup> Gene Mutation at Position 3243 Regine Becker, H. Laube, Thomas Linn, Experimental and Clinical Endocrinology & Diabetes	2002	21

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