SPARC is expressed in human uveal melanoma and its abrogation reduces tumor cell proliferation.

SPARC may represent a novel target to inhibit growth of UM.

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	Year	Citations
Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM Rolf A. Brekken, Pauli Puolakkainen, David C. Graves, Journal of Clinical Investigation ImmunologyBiological MicroenvironmentsPathologyImmunoeditingCell Proliferation	2003	195
Leukocyte, Rather than Tumor-produced SPARC, Determines Stroma and Collagen Type IV Deposition in Mammary Carcinoma Sabina Sangaletti, Antonella Stoppacciaro, Cristiana Guiducci, The Journal of Experimental Medicine	2003	132
Cell cycle-dependent nuclear location of the matricellular protein SPARC: Association with the nuclear matrix Michel D. Gooden, Robert B. Vernon, James A. Bassuk, Journal of Cellular Biochemistry OocyteNuclear StructureImmunologyMolecular BiologyCell Culture	1999	75
Transcriptional profiling of human uveal melanoma from cell lines to intraocular tumors to metastasis Jean‐Claude Marshall, André Nantel, Paula Blanco, Clinical & Experimental Metastasis Transcriptional ProfilingOphthalmologyHuman Uveal MelanomaPhotocarcinogenesisMelanoma	2007	29
Differential expression of angioregulatory matricellular proteins in posterior uveal melanoma José Luis Ordóñez, Luminita Paraoan, Paul Hiscott, Melanoma Research Ocular DiseaseAngiogenesisVascular BedOphthalmologyPhotocarcinogenesis	2005	14
In vitro characterization and inhibition of the CXCR4/CXCL12 chemokine axis in human uveal melanoma cell lines Sebastian Di Cesare, Jean‐Claude Marshall, Bruno F. Fernandes, Cancer Cell International	2007	14

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