Concepedia

Mutant p53 Amplifies Epidermal Growth Factor Receptor Family Signaling to Promote Mammary Tumorigenesis

Alisha R. Yallowitz, Dun Li, Anthony Lobko, Daniel Mott, Alice Nemajerová, Natalia Marchenko

Molecular Cancer Research · 2015 · 36 citations · 45 references

DOIFull text

Open access

Abstract

This study identifies mutant p53 as an essential player in ErbB2 and EGFR-mediated mammary tumorigenesis and indicates the potential translational importance of targeting mutant p53 in this subset of patients with breast cancer.

References

45

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ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome

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