Simvastatin Alleviates Diabetes-Induced VEGF-Mediated Nephropathy via the Modulation of Ras Signaling Pathway

Abstract

Ras protein activation is a key mediator of VEGF-induced diabetic nephropathy. By inhibiting Ras activation, simvastatin modulates the high glucose-induced VEGF-mediated signaling pathway in vitro and in vivo.