Simvastatin Alleviates Diabetes-Induced VEGF-Mediated Nephropathy via the Modulation of Ras Signaling Pathway - Concepedia

Concepedia

Publication | Open Access

Simvastatin Alleviates Diabetes-Induced VEGF-Mediated Nephropathy via the Modulation of Ras Signaling Pathway

DOI Full Paper Access

15

Citations

23

References

2008

Year

Cheng Ho, Yen-Chen Hsu, Ching-Cheng Tseng, Feng‐Sheng Wang, Chun‐Liang Lin, Jeng Yi Wang

Abstract

Ras protein activation is a key mediator of VEGF-induced diabetic nephropathy. By inhibiting Ras activation, simvastatin modulates the high glucose-induced VEGF-mediated signaling pathway in vitro and in vivo.

References

	Year	Citations
Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes. Mark E. Cooper, Dimitria Vranes, Sherif Youssef, Diabetes ImmunologyRenal InflammationReceptor Vegfr-2Experimental DiabetesRenal Expression	1999	473
Rho and Rac but not Cdc42 regulate endothelial cell permeability Beata Wójciak‐Stothard, Sandra Potempa, Thomas Eichholtz, Journal of Cell Science	2001	463
Antibodies against Vascular Endothelial Growth Factor Improve Early Renal Dysfunction in Experimental Diabetes An S. De Vriese, Ronald G. Tilton, Marlies Elger, Journal of the American Society of Nephrology	2001	442
Diabetic Endothelial Nitric Oxide Synthase Knockout Mice Develop Advanced Diabetic Nephropathy Takahiko Nakagawa, Waichi Sato, Olena Glushakova, Journal of the American Society of Nephrology	2007	365
Hypoxia-Inducible Factor-1 Mediates Activation of Cultured Vascular Endothelial Cells by Inducing Multiple Angiogenic Factors Midori Yamakawa, Louis X. Liu, Taro Date, Circulation Research ImmunologyPathologyVascular LeakageCellular PhysiologyOxidative Stress	2003	321
Amelioration of Long-Term Renal Changes in Obese Type 2 Diabetic Mice by a Neutralizing Vascular Endothelial Growth Factor Antibody Allan Flyvbjerg, Frederik Dagnæs‐Hansen, An S. De Vriese, Diabetes Renal PathologyImmunologyDiabetic MicePathologyVegf Antibody	2002	307
3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy Farhad R. Danesh, Mehran M. Sadeghi, Nail Amro, Proceedings of the National Academy of Sciences	2002	230
Expression of Concern: Inhibition of endothelial cell migration by cerivastatin, an HMG‐CoA reductase inhibitor: contribution to its anti‐angiogenic effect Loı̈c Vincent, Wenming Chen, Hong Li, FEBS Letters	2001	205
Aldose Reductase Inhibitor Fidarestat Prevents Retinal Oxidative Stress and Vascular Endothelial Growth Factor Overexpression in Streptozotocin-Diabetic Rats Irina G. Obrosova, Rukmini Vasupuram, Lauren White, Diabetes	2003	202
Blockade of Vascular Endothelial Growth Factor Signaling Ameliorates Diabetic Albuminuria in Mice Sun Hee Sung, Fuad N. Ziyadeh, Amy Wang, Journal of the American Society of Nephrology InflammationRenal FunctionMicrovascular DysfunctionChronic Kidney DiseaseAtherosclerosis	2006	196

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