Concepedia

Vaccination With Irradiated Autologous Tumor Cells Engineered to Secrete Granulocyte-Macrophage Colony-Stimulating Factor Augments Antitumor Immunity in Some Patients With Metastatic Non–Small-Cell Lung Carcinoma

Ravi Salgia, Thomas J. Lynch, Arthur T. Skarin, Joan Lucca, C Lynch, Ken Jung, F. Stephen Hodi, Michael T. Jaklitsch, S.J. Mentzer, Jean Lukanich,

Journal of Clinical Oncology · 2003 · 294 citations · 33 references

DOI

Abstract

Vaccination with irradiated autologous NSCLC cells engineered to secrete GM-CSF enhances antitumor immunity in some patients with metastatic NSCLC.

References

33

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

Glen Dranoff, Elizabeth M. Jaffee, A Lazenby et al. · Proceedings of the National Academy of Sciences · 1993 · 2.8K citations · Full text

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Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

Alex Y. Huang, Paul T. Golumbek, Mojgan Ahmadzadeh et al. · Science · 1994 · 1.2K citations

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Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

Andrea van Elsas, Arthur A. Hurwitz, James P. Allison · The Journal of Experimental Medicine · 1999 · 1K citations · Full text

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Construction of adenovirus vectors through Cre-lox recombination

S. Hardy, Marina Kitamura, T Harris-Stansil et al. · Journal of Virology · 1997 · 796 citations · Full text

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Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism

Bryan R. Cullen · Cell · 1986 · 690 citations

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