Concepedia

Validation of SAG/RBX2/ROC2 E3 Ubiquitin Ligase as an Anticancer and Radiosensitizing Target

Lijun Jia, Jie Yang, Xinbao Hao, Min Zheng, Hongbin He, Xiufang Xiong, Liang Xu, Yi Sun

Clinical Cancer Research · 2010 · 89 citations · 25 references

DOIFull text

Open access

Abstract

The findings showed that SAG E3 ubiquitin ligase plays an essential role in cancer cell proliferation and tumor growth and may serve as a promising anticancer and radiosensitizing target.

References

25

Global Protein Stability Profiling in Mammalian Cells

Hsueh-Chi S. Yen, Qikai Xu, Danny M. Chou et al. · Science · 2008 · 488 citations

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FBXW7 Targets mTOR for Degradation and Cooperates with PTEN in Tumor Suppression

Jian‐Hua Mao, Il-Jin Kim, Di Wu et al. · Science · 2008 · 417 citations · Full text

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Differential Regulation of Noxa in Normal Melanocytes and Melanoma Cells by Proteasome Inhibition: Therapeutic Implications

Yolanda Fernández, Monique Verhaegen, Thomas P. Miller et al. · Cancer Research · 2005 · 224 citations

Identification of SCF Ubiquitin Ligase Substrates by Global Protein Stability Profiling

Hsueh-Chi S. Yen, Stephen J. Elledge · Science · 2008 · 208 citations

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Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition

Mikhail A. Nikiforov, MaryBeth Riblett, W. H. Wilson Tang et al. · Proceedings of the National Academy of Sciences · 2007 · 175 citations · Full text