LacI transgenic animal study: relationships among DNA-adduct levels, mutant frequencies and cancer incidences

A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-<i>b</i>]pyridine (PhIP)

Nobuyuki Ito, Ryohei Hasegawa, Masashi Sano et al. · Carcinogenesis · 1991 · 540 citations

Medicine, Oncology, Toxicology +9

The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods.

Tsuyoshi Shirai, M. Sano, Seiko Tamano et al. · PubMed · 1997 · 395 citations

Medicine, Cancer Biology, Oncology +15

Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps.

Nicholas P. Lang, Marguerite A. Butler, Joyce Massengill et al. · PubMed · 1994 · 392 citations

Medicine, Pharmacology, Toxicology +17

³²P-Postlabeling analysis of DNA adducts persisting for up to 42 weeks in the skin, epidermis and dermis of mice treated topically with 7,12-dimethylbenz[a]anthracene

Erika Randerath, Hari P. Agrawal, James Weaver et al. · Carcinogenesis · 1985 · 156 citations

Pharmacy, Dermatology, Toxicology +13

Specific 5'-GGGA-3'--&gt;5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

H Kakiuchi, Masatoshi Watanabe, Toshikazu Ushijima et al. · Proceedings of the National Academy of Sciences · 1995 · 150 citations · Full text

Medicine, Genetics, Oncology +16