Pre-eclampsia and lipid profile.

Abstract

The present study was designed to evaluate the role of lipid profile alteration in the development of Pre-eclampsia. We selected 32 pregnant women 16 healthy pregnant women (mean age 25.56+or-3.68) as normal and 16 already diagnosed preeclamptic women (mean age 24.65+or-4.25) as study group. Serum lipid profile (total lipids cholesterol triglycerides HDL-cholesterol and LDL-cholesterol) of thirty two women with Pre-eclampsia (n=16) normotensive women (n=16) were monitored. The serum triglyceride concentrations increased significantly (232.18+or-106.41 vs. 113.12 +or-21.3 P<0.01) while Serum HDL-cholesterol concentrations decreased significantly (39.75+or-11.99 vs. 51.18+or-06.09 P<0.01) in preeclamptic group as compared to normal pregnant women. Lipid metabolism plays a key role in the pathophysiology of Pre-eclampsia. Increased triglycerides levels along with decreased HDL-cholesterol levels and delayed triglycerides clearance and high blood pressure are associated with development of preeclampsia. (authors)