Drug-inducible and simultaneous regulation of endogenous genes by single-chain nuclear receptor-based zinc-finger transcription factor gene switches

Krüppel-associated boxes are potent transcriptional repression domains.

Judith Margolin, Joshua R. Friedman, Wolfram Meyer et al. · Proceedings of the National Academy of Sciences · 1994 · 627 citations · Full text

Life Sciences, Biology, Molecular Biology +15

Toward controlling gene expression at will: Specific regulation of the <i>erbB</i> - <i>2</i> / <i>HER</i> - <i>2</i> promoter by using polydactyl zinc finger proteins constructed from modular building blocks

Roger R. Beerli, David J. Segal, Birgit Dreier et al. · Proceedings of the National Academy of Sciences · 1998 · 538 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences

David J. Segal, Birgit Dreier, Roger R. Beerli et al. · Proceedings of the National Academy of Sciences · 1999 · 423 citations

Life Sciences, Biology, Molecular Biology +17

PPARγ knockdown by engineered transcription factors: exogenous PPARγ2 but not PPARγ1 reactivates adipogenesis

Delin Ren, Trevor N. Collingwood, Edward J. Rebar et al. · Genes & Development · 2002 · 356 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Positive and negative regulation of endogenous genes by designed transcription factors

Roger R. Beerli, Birgit Dreier, Carlos F. Barbas · Proceedings of the National Academy of Sciences · 2000 · 348 citations

Life Sciences, Cancer Biology, Molecular Biology +17