Concepedia

Comparison of Immortalized Fa2N-4 Cells and Human Hepatocytes as in Vitro Models for Cytochrome P450 Induction

Niresh Hariparsad, Brian Carr, Raymond Evers, Xiaoyan Chu

Drug Metabolism and Disposition · 2008 · 87 citations · 23 references

Concepts

MedicineBiochemistryPharmacologyBiochemical PharmacologyCellular PharmacologyMolecular PharmacologyCytochrome P450-mediated MetabolismDrug DispositionEnzyme InductionHepatic Drug MetabolismHepatic MetabolismConstitutive Androstane Receptor SignalingConstitutive Receptor ActivityCytochrome P450 3A4 MetabolismHepatic Drug TransportersHepatic TransportersHuman Cell-based In Vitro ModelsInduction In HepatocytesMetabolic Enzyme Induction

References

23

A new mathematical model for relative quantification in real-time RT-PCR

Michael W. Pfaffl · Nucleic Acids Research · 2001 · 34.9K citations · Full text

Life Sciences, Molecular Biology, Gene Expression +12

Nuclear receptor that identifies a novel retinoic acid response pathway

David J. Mangelsdorf, Estelita S. Ong, Jacqueline A. Dyck et al. · Nature · 1990 · 1.5K citations

Life Sciences, Cell Biology, Molecular Biology +14

SXR, a novel steroid and xenobioticsensing nuclear receptor

Bruce Blumberg, Walid Sabbagh, Henry Juguilon et al. · Genes & Development · 1998 · 920 citations · Full text

Life Sciences, Endocrinology, Molecular Biology +17

CYP3A4 Induction by Drugs: Correlation between a Pregnane X Receptor Reporter Gene Assay and CYP3A4 Expression in Human Hepatocytes

Gang Luo, Mark R. Cunningham, Sean Kim et al. · Drug Metabolism and Disposition · 2002 · 447 citations

Medicine, Pharmacology, Biochemical Pharmacology +15

Identification of a Novel Human Constitutive Androstane Receptor (CAR) Agonist and Its Use in the Identification of CAR Target Genes

Jodi M. Maglich, Derek J. Parks, Linda B. Moore et al. · Journal of Biological Chemistry · 2003 · 415 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16