Concepedia

The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma

Jaehyouk Lee, Dongjun Jeong, Jin‐Sun Kim, Soonduck Lee, Jin-Hwa Park, Boogi Chang, Samil Jung, Lisha Yi, Young‐Soo Han, Young Yang,

Molecular Cancer · 2010 · 150 citations · 20 references

DOIFull text

Open access

Abstract

Epigenetic silencing of KLOTHO may occur during the late phase of cervical tumorigenesis, and consequent functional loss of KLOTHO as the secreted Wnt antagonist may contribute to aberrant activation of the canonical Wnt pathway in cervical carcinoma.

References

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