5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series

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Lori A. Kohlstaedt, J Wang, Jonathan M. Friedman et al. · Science · 1992 · 1.9K citations

Crystal Structure, Viral Replication, Active Sites +19

High resolution structures of HIV-1 RT from four RT–inhibitor complexes

Jingshan Ren, Robert Esnouf, Elspeth F. Garman et al. · Nature Structural & Molecular Biology · 1995 · 498 citations

Biochemistry, Natural Sciences, Human Retrovirus +8

Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors

Robert Esnouf, Jingshan Ren, Carl Ross et al. · Nature Structural & Molecular Biology · 1995 · 439 citations

Human Retrovirus, Immunology, Hiv-1 Reverse Transcriptase +8

Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative

Masanori Baba, H. TANAKA, Erik De Clercq et al. · Biochemical and Biophysical Research Communications · 1989 · 287 citations

Medicinal Chemistry, Medicine, Immunology +7

Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor α-APA R 95845 at 2.8 å resolution

Jianping Ding, Kalyan Das, Chris Tantillo et al. · Structure · 1995 · 209 citations · Full text

Virus Structure, Viral Replication, Viral Polymerase Structure +9