Mutant Adenosine Deaminase 2 in a Polyarteritis Nodosa Vasculopathy

Abstract

Recessive loss-of-function mutations of ADA2, a growth factor that is the major extracellular adenosine deaminase, can cause polyarteritis nodosa vasculopathy with highly varied clinical expression. (Funded by the Shaare Zedek Medical Center and others.).