Concepedia

Rolapitant for the Prevention of Postoperative Nausea and Vomiting

Tong J. Gan, Jiezhun Gu, Neil Singla, Frances Chung, Michael H. Pearman, Sergio D. Bergese, Ashraf S. Habib, Keith Candiotti, Mo Yi, Susan Huyck,

Anesthesia & Analgesia · 2011 · 64 citations · 12 references

DOI

Abstract

Rolapitant is superior to placebo in reducing emetic episodes after surgery and reduces the incidence of vomiting in a dose-dependent manner. No differences in side effect profile were observed between rolapitant and placebo.

References

12

Society for Ambulatory Anesthesia Guidelines for the Management of Postoperative Nausea and Vomiting

Tong J. Gan, Tricia A. Meyer, Christian C. Apfel et al. · Anesthesia & Analgesia · 2007 · 710 citations

The distribution of substance P and 5‐hydroxytryptamine in the central nervous system of the dog

T. B. B. Crawford, J. H. Gaddum · The Journal of Physiology · 1954 · 698 citations · Full text

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Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets

F.D. Tattersall, Wayne Rycroft, B. Francis et al. · Neuropharmacology · 1996 · 211 citations

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A Randomized, Double-Blind Comparison of the NK1 Antagonist, Aprepitant, Versus Ondansetron for the Prevention of Postoperative Nausea and Vomiting

Tong J. Gan, Christian C. Apfel, Anthony L. Kovac et al. · Anesthesia & Analgesia · 2007 · 191 citations

Antiemetic activity of the NK1 receptor antagonist GR205171 in the treatment of established postoperative nausea and vomiting after major gynaecological surgery

Pierre Diemunsch, P. Schoeffler, B. Bryssine et al. · British Journal of Anaesthesia · 1999 · 167 citations · Full text

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