Rapid Detection of <i>S</i>‐Adenosyl Homocysteine Using Self‐Assembled Optical Diffraction Gratings

Abstract

I saw the SAH: Clinically relevant concentrations of S-adenosyl homocysteine (SAH) can be rapidly detected using self-assembled diffraction gratings. SAH bound to antibody-conjugated (Ab) microbeads (see picture) and then incubated with a gold chip functionalized with SAH-specific aptamer in alternating line patterns produces gratings that are detected by optical diffraction intensity measurements (detection limit: 64 pmol L−1). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z703222_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.