Concepedia

A Novel Class of Endotoxin Receptor Agonists with Simplified Structure, Toll-Like Receptor 4-Dependent Immunostimulatory Action, and Adjuvant Activity

Lynn D. Hawkins, Sally T. Ishizaka, Pamela D. McGuinness, Huiming Zhang, Wendy Gavin, Bruce Decosta, Zhaoyang Meng, Yang Hu, Maureen Mullarkey, Donna W. Young,

Journal of Pharmacology and Experimental Therapeutics · 2002 · 62 citations · 19 references

DOI

Concepts

References

19

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

Alexander Poltorak, Xiaolong He, Irina Smirnova et al. · Science · 1998 · 7.6K citations

, , +17

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Ruslan Medzhitov, Paula Preston‐Hurlburt, Charles A. Janeway · Nature · 1997 · 5.5K citations

, , +13

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai et al. · The Journal of Immunology · 1999 · 3.4K citations · Full text

, , +15

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

Adrian Ozinsky, David M. Underhill, Jason D. Fontenot et al. · Proceedings of the National Academy of Sciences · 2000 · 2.1K citations · Full text

, , +17

Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction

Jesse C. Chow, Donna W. Young, Douglas T. Golenbock et al. · Journal of Biological Chemistry · 1999 · 2K citations · Full text

, , +17