Concepedia

Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription

Akira Takeshita, Noriyuki Koibuchi, Jun‐Ichiro Oka, Madoka Taguchi, Yoshimasa Shishiba, Y Ozawa

European Journal of Endocrinology · 2001 · 130 citations · 23 references

DOI

Abstract

Our observations have indicated that BPA may be a human-specific inducer of the CYP3A4 gene, and may influence the metabolism of endogenous steroids, drugs, and other xenobiotics.

References

23

Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β

George G. J. M. Kuiper, Josephine G. Lemmen, Bo Carlsson et al. · Endocrinology · 1998 · 4.2K citations

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The coregulator exchange in transcriptional functions of nuclear receptors

Christopher K. Glass, Michael G. Rosenfeld · Genes & Development · 2000 · 2.2K citations · Full text

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J�rgen Lehmann, David D. McKee, M. A. Watson et al. · Journal of Clinical Investigation · 1998 · 1.6K citations · Full text

, , +18

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

Steven A. Kliewer, John T. Moore, Laura Wade et al. · Cell · 1998 · 1.5K citations · Full text

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Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving.

Arunkumar Krishnan, P Stathis, Steve Permuth et al. · Endocrinology · 1993 · 1.5K citations

, , +18