Modeling of the 5′‐Deiodination of Thyroxine by Iodothyronine Deiodinase: Chemical Corroboration of a Selenenyl Iodide Intermediate

Abstract

What makes a good cavity? A molecular cavity enabled the stabilization of a selenenyl iodide (RSeI) intermediate formed in 5′-deiodination of a thyroxine derivative by an organoselenol (see scheme). The chemical processes proposed for the iodothyronine deiodinase catalytic cycle were experimentally established.