Concepedia

Thyroxine Biosynthesis

Thyroxine Biosynthesis is the biochemical process by which the thyroid gland synthesizes thyroxine (T4) through the iodination and coupling of tyrosine residues on thyroglobulin, distinguishing it as the primary endogenous pathway for generating the prohormone precursor of active thyroid hormone.

719

Publications

31.9K

Citations

2K

Authors

582

Institutions

Publications per year

2017–2026

18

Variants

T4 Biosynthesis

Parents

Publications

719

Maternal-Fetal Transfer of Thyroxine in Congenital Hypothyroidism Due to a Total Organification Defect or Thyroid Agenesis

Thomas Vulsma, Margareth H. Gons, Jan J. M. de Vijlder · New England Journal of Medicine · 1989 · 807 citations

, , +16

Depletion of L-3,5,3'-Triiodothyronine and L-Thyroxine in Euthyroid Calf Serum for Use in Cell Culture Studies of the Action of Thyroid Hormone*

Herbert H. Samuels, Frederick M. Stanley, Juan Casanova · Endocrinology · 1979 · 649 citations

, , +13

Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans

Ana Luiza Maia · Journal of Clinical Investigation · 2005 · 367 citations · Full text

, , +13

Chemistry of Thyroxine

C. R. Harington, George Barger · Biochemical Journal · 1927 · 321 citations · Full text

, , +5

Central Hypothyroidism Associated with Retinoid X Receptor–Selective Ligands

Steven I. Sherman, Jayashree Gopal, Bryan R. Haugen et al. · New England Journal of Medicine · 1999 · 319 citations

, , +17

1–5 of 719

Authors

2K

  1. JE
    J.G. Eales

    University of Manitoba, Canada

    16 publications · 755 citations

    16

    h-index

  2. SH
    Sidney H. Ingbar

    Harvard University, United States

    13 publications · 825 citations

    13

    h-index

  3. LE
    Lewis E. Braverman

    University of Massachusetts Chan Medical School, United States

    12 publications · 646 citations

    12

    h-index

  4. IJ
    INDER J. CHOPRA

    Oklahoma State University Center for Health Sciences, United States

    11 publications · 942 citations

    11

    h-index

  5. HJ
    H. J. Cahnmann

    National Institutes of Health, United States

    9 publications · 219 citations

    9

    h-index

1–5 of 2K

Institutions

582

  1. Harvard University

    Cambridge, United States

    28 h-index

    112 publications

    7.5K citations

  2. Brigham and Women's Hospital

    Boston, United States

    18 h-index

    56 publications

    4.5K citations

  3. University of California, Berkeley

    Berkeley, United States

    15 h-index

    49 publications

    3K citations

  4. University of Manitoba

    Winnipeg, Canada

    15 h-index

    32 publications

    1.4K citations

  5. University of California, Los Angeles

    Los Angeles, United States

    13 h-index

    46 publications

    2K citations

  6. Inserm

    Paris, France

    12 h-index

    55 publications

    2.3K citations

  7. University of Massachusetts Chan Medical School

    Worcester, United States

    11 h-index

    37 publications

    1.9K citations

  8. United States Department of Veterans Affairs

    Washington, United States

    11 h-index

    32 publications

    1.3K citations

1–8 of 582

Venues

  1. Endocrinology

    91 publications · 5.1K citations

    36

    h-index

  2. General and Comparative Endocrinology

    60 publications · 2.7K citations

    32

    h-index

  3. Journal of Biological Chemistry

    JBC · 31 publications · 1.5K citations

    23

    h-index

  4. The Journal of Clinical Endocrinology & Metabolism

    JCEM · 34 publications · 1.4K citations

    22

    h-index

  5. Journal of Clinical Investigation

    JCI · 20 publications · 2.8K citations

    20

    h-index

1–5