Concepedia

Activation Pattern of Signal Transducers and Activators of Transcription (STAT) Factors in Inflammatory Bowel Diseases

Jonas Mudter, Benno Weigmann, Brigitte Bartsch, Dennis Strand, Peter R. Galle, Hans A. Lehr, Jan Schmidt, Markus F. Neurath

The American Journal of Gastroenterology · 2005 · 229 citations · 31 references

DOI

Abstract

The analysis of STAT activation patterns could serve as a helpful tool to characterize intestinal inflammation. Furthermore, the IL-6/STAT-3 rather than the IFN-gamma/STAT-1 signaling pathway emerges as a key target for the development of future therapeutic concepts in IBD.

References

31

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

Marco Antonio Meraz‐Ríos, J. Michael White, Kathleen C. F. Sheehan et al. · Cell · 1996 · 1.7K citations · Full text

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Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

Mark H. Kaplan, Ulrike Schindler, Stephen T. Smiley et al. · Immunity · 1996 · 1.6K citations · Full text

, , +10

Essential role of Stat6 in IL-4 signalling

Takashi Tanaka, Wei Shi, Makoto Matsumoto et al. · Nature · 1996 · 1.6K citations

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Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

Kazuya Shimoda, Jan van Deursent, Mark Y. Sangster et al. · Nature · 1996 · 1.3K citations

, , +10

Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo

Raja Atreya, Jonas Mudter, Susetta Finotto et al. · Nature Medicine · 2000 · 1.3K citations

, , +11