The Site-Specific Transport and Metabolism of Tacrolimus in Rat Small Intestine

Expression of a multidrug-resistance gene in human tumors and tissues.

Antonio Tito Fojo, Kazumitsu Ueda, Dennis J. Slamon et al. · Proceedings of the National Academy of Sciences · 1987 · 1.6K citations · Full text

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FK 506 FOR LIVER, KIDNEY, AND PANCREAS TRANSPLANTATION

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Characterization of Interintestinal and Intraintestinal Variations in Human CYP3A-Dependent Metabolism

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Interrelationship Between Substrates and Inhibitors of Human CYP3A and P-Glycoprotein

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Medicine, Pharmacokinetics, Pharmacology +10

Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat.

Martin Sattler, F. Peter Guengerich, Chul‐Ho Yun et al. · Drug Metabolism and Disposition · 1992 · 389 citations

Medicine, Biochemistry, Pharmacology +17