Catalytic Asymmetric Addition of Alkyl Enol Ethers to 1,2‐Dicarbonyl Compounds: Highly Enantioselective Synthesis of Substituted 3‐Alkyl‐3‐Hydroxyoxindoles

Abstract

A familiar ring: An efficient catalytic asymmetric hetero-ene reaction of 1,2-dicarbonyl compounds (including isatins, α-ketoesters, and glyoxal derivatives) is described. The catalyst system derived from 1 can be used for a broad substrate scope and the corresponding products were obtained in good yield and excellent enantioselectivity. M.S.=molecular sieves. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.