Concepedia

Oxidative stress induces anti-hepatitis C virus status via the activation of extracellular signal-regulated kinase #

Masahiko Yano, Masanori Ikeda, Kenichi Abe, Yoshinari Kawai, Misao Kuroki, Kyoko Mori, Hiromichi Dansako, Yasuo Ariumi, Shougo Ohkoshi, Yutaka Aoyagi,

Hepatology · 2009 · 47 citations · 39 references

DOIFull text

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Abstract

Our results demonstrate the involvement of the MEK-ERK1/2 signaling pathway in the anti-HCV status induced by oxidative stress in a broad range of anti-HCV reagents. This intracellular modulation is expected to be a therapeutic target for the suppression of HCV RNA replication.

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