Antimicrobial Agents and Chemotherapy · 2006 · 33 citations · 18 references
Life SciencesMolecular BiologyMolecular GeneticsMolecular VirologyVirologyAntiviral Drug ResistanceAntiviral ResistanceViral GeneticsViral GenomicsViral MutationVirus Genome OrganizationAcyclovir TherapyAntiviral Resistance MechanismsAntiviral Resistance MutationsHerpesvirus Drug ResistanceResistance Mutation MappingResistance PathwaysResistance-associated MutationsVirus Resistance Traits
Contributions of thymidine kinase (TK) mutations to acyclovir (ACV) resistance were evaluated in herpes simplex virus type 1 recombinant viruses generated using a set of overlapping cosmids and plasmids. Alterations in both conserved and nonconserved regions of the TK gene were shown to confer high levels of resistance to ACV.
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