Concepedia

Interindividual variability in sensitivity to warfarin-Nature or nurture?

Ronen Loebstein

Clinical Pharmacology & Therapeutics · 2001 · 260 citations · 19 references

DOI

Abstract

At optimized steady state, individual sensitivity to warfarin is determined by CYP2C9 genotype and age with no effect of vitamin K. Prospective studies will determine the impact of these findings in clinical practice.

References

19

Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications

Guruprasad P. Aithal, Christopher P. Day, Patrick Kesteven et al. · The Lancet · 1999 · 1.2K citations

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Geigy scientific tables

J. R. Geigy · Medical Entomology and Zoology · 1981 · 1.2K citations

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Acetaminophen and Other Risk Factors for Excessive Warfarin Anticoagulation

Elaine M. Hylek · JAMA · 1998 · 377 citations

Genetic association between sensitivity to warfarin and expression of CYP2C9*3

Daniel J. Steward, Robert L. Haining, Kirk R. Henne et al. · Pharmacogenetics · 1997 · 307 citations

Genetic analysis of the human cytochrome P450 CYP2C9 locus

Michael J. Stubbins, Lorna W. Harries, Gillian Smith et al. · Pharmacogenetics · 1996 · 303 citations

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