Association Testing of Novel Type 2 Diabetes Risk Alleles in the <i>JAZF1</i>, <i>CDC123</i>/<i>CAMK1D</i>, <i>TSPAN8</i>, <i>THADA</i>, <i>ADAMTS9</i>, and <i>NOTCH2</i> Loci With Insulin Release, Insulin Sensitivity, and Obesity in a Population-Based Sample of 4,516 Glucose-Tolerant Middle-Aged Danes

Abstract

If replicated, our data suggest that type 2 diabetes at-risk alleles in the JAZF1, CDC123/CAMK1D, and TSPAN8 loci associate with various OGTT-based surrogate measures of insulin release, emphasizing the contribution of abnormal pancreatic beta-cell function in the pathogenesis of type 2 diabetes.