Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9

Circulating mitochondrial DAMPs cause inflammatory responses to injury

Qin Zhang, Mustafa Raoof, Yu Chen et al. · Nature · 2010 · 3.7K citations · Full text

Life Sciences, Cell Biology, Immunology +12

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Kiichi Nakahira, Jeffrey A. Haspel, Vijay Rathinam et al. · Nature Immunology · 2010 · 3K citations · Full text

Life Sciences, Cell Biology, Immunology +15

Mitochondrial Complex I Inhibitor Rotenone Induces Apoptosis through Enhancing Mitochondrial Reactive Oxygen Species Production

Nianyu Li, Kathy Ragheb, Gretchen Lawler et al. · Journal of Biological Chemistry · 2003 · 1.4K citations · Full text

Life Sciences, Cell Biology, Pharmacology +17

Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

Jane Tian, Ana M. Avalos, Su-Yau Mao et al. · Nature Immunology · 2007 · 1.4K citations

Life Sciences, Immunology, Molecular Biology +12

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

Eicke Latz, Annett Schoenemeyer, Alberto Visintin et al. · Nature Immunology · 2004 · 1.3K citations

Life Sciences, Immunology, Molecular Biology +6